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    Growth Hormone Secretagogue Receptor Type 1-Pipeline Review H2 2017

    Growth Hormone Secretagogue Receptor Type 1-Pipeline Review H2 2017

    • Report Code ID: RW00011199531
    • Category Life Sciences
    • No. of Pages 75
    • Publication Month Oct-17
    • Publisher Name Global Markets Direct
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Pipeline Review, H2 2017

    Summary

    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Growth hormone secretagogue receptor (GHSR) also known as ghrelin receptor, is a G protein-coupled receptor that binds ghrelin. Ghrelin is an appetite-regulating factor secreted from peripheral organs via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity.

    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) pipeline Target constitutes close to 19 molecules. Out of which approximately 18 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Filing rejected/Withdrawn, Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 1, 3, 1, 9 and 3 respectively. Similarly, the universities portfolio in Phase II stages comprises 1 molecules, respectively. Report covers products from therapy areas Oncology, Toxicology, Metabolic Disorders, Central Nervous System, Cardiovascular, Genetic Disorders, Gastrointestinal, Genito Urinary System And Sex Hormones, Hormonal Disorders and Infectious Disease which include indications Cancer Anorexia-Cachexia Syndrome, Obesity, Prader-Willi Syndrome (PWS), Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome), Acute Ischemic Stroke, Alcohol Addiction, Chemotherapy Effects, Chemotherapy Induced Peripheral Neuropathy, Chronic Kidney Disease (Chronic Renal Failure), Diabetes, Diabetic Gastroparesis, Fatigue, Growth Hormone Deficiency, Ischemia, Opioid-Induced Bowel Dysfunction (OBD or OIBD), Sepsis and Traumatic Brain Injury.

    The latest report Growth Hormone Secretagogue Receptor Type 1-Pipeline Review, H2 2017, outlays comprehensive information on the Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics development with respective active and dormant or discontinued projects.

    The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

    Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

    Scope

    -The report provides a snapshot of the global therapeutic landscape for Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)
    -The report reviews Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
    -The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
    -The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
    -The report reviews key players involved in Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics and enlists all their major and minor projects
    -The report assesses Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
    -The report summarizes all the dormant and discontinued pipeline projects
    -The report reviews latest news and deals related to Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics

    Reasons to buy

    -Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
    -Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
    -Identify and understand the targeted therapy areas and indications for Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)
    -Identify the use of drugs for target identification and drug repurposing
    -Identify potential new clients or partners in the target demographic
    -Develop strategic initiatives by understanding the focus areas of leading companies
    -Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
    -Devise corrective measures for pipeline projects by understanding Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) development landscape
    -Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
    Table of Contents
    List of Tables
    List of Figures
    Introduction
    Publisher Report Coverage
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Overview
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Therapeutics Development
    Products under Development by Stage of Development
    Products under Development by Therapy Area
    Products under Development by Indication
    Products under Development by Companies
    Products under Development by Universities/Institutes
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Therapeutics Assessment
    Assessment by Mechanism of Action
    Assessment by Route of Administration
    Assessment by Molecule Type
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Companies Involved in Therapeutics Development
    Aeterna Zentaris Inc
    Alize Pharma SAS
    Allergan Plc
    AstraZeneca Plc
    Daiichi Sankyo Co Ltd
    Oxeia Biopharmaceuticals Inc
    Pfizer Inc
    RaQualia Pharma Inc
    Zeria Pharmaceutical Co Ltd
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Drug Profiles
    anamorelin hydrochloride-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    AZ-12861903-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    AZP-531-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    EXT-400-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    EXT-405-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    HM-01-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    HM-03-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    HM-04-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    ibutamoren mesylate-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    macimorelin acetate-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    OXE-103-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    Peptide to Agonize GHSR for Acute Ischemic Stroke, Acute Radiation Syndrome and Sepsis-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    PF-05190457-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    relamorelin-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    RQ-00433412-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    Small Molecule to Antagonize Ghrelin Receptor for Obesity-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    Small Molecule to Antagonize Ghrelin Receptor for Obesity-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    Synthetic Peptide to Modulate GHSR for Chronic Kidney Disease-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    Z-505-Drug Profile
    Product Description
    Mechanism Of Action
    R&D Progress
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Dormant Products
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Discontinued Products
    Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)-Product Development Milestones
    Featured News & Press Releases
    Sep 15, 2017: Refusal of the marketing authorization for Adlumiz (anamorelin hydrochloride)
    Sep 06, 2017: Oxeia Biopharmaceuticals Announces Appointment Of Dr. Michael Wyand As Chief Executive Officer
    Aug 23, 2017: Richard Sherman, NFL All-Pro, Joins Oxeia Biopharmaceuticals Advisory Board
    Jul 18, 2017: NDA for Macrilen for the Evaluation of Growth Hormone Deficiency in Adults Granted December 30, 2017 PDUFA Date
    Jun 30, 2017: Aeterna Zentaris Resubmits NDA for Macrilen for the Evaluation of Growth Hormone Deficiency in Adults
    Jun 19, 2017: Ammonett Pharma Granted Orphan Drug Designation From the U.S. FDA for Ibutamoren Mesylate (MK-0677) for Treatment of Growth Hormone Deficiency
    May 25, 2017: Ammonett Pharma Receives Notice of Allowance of U.S. Patent for Oratrope Related to Detecting and Treating Growth Hormone Deficiency
    May 23, 2017: Ammonett Pharma Receives Positive Opinion from European Orphan Medicinal Products Committee for MK-0677 for Treatment of Pediatric Growth Hormone Deficiency
    May 18, 2017: Helsinn Announces Refusal of the marketing authorisation for Adlumiz (anamorelin hydrochloride)
    May 01, 2017: Allergan to Present Data on Relamorelin at Digestive Disease Week 2017
    Mar 30, 2017: Aeterna Zentaris Intends to File NDA with Respect to Macrilen in Third Quarter of 2017
    Mar 07, 2017: Aeterna Zentaris Announces EMA Pediatric Committee Agreement on the Pediatric Investigation Plan for Macrilen
    Mar 02, 2017: Aeterna Zentaris Announces Presentation Regarding Macrilen at 99th Annual Meeting of the Endocrine Society
    Feb 13, 2017: Aeterna Zentaris Announces Plans to Pursue FDA Registration of Macrilen
    Jan 04, 2017: Aeterna Zentaris Announces Top-Line Results of Confirmatory Phase 3 Trial of Macrilen
    Appendix
    Methodology
    Coverage
    Secondary Research
    Primary Research
    Expert Panel Validation
    Contact Us
    Disclaimer

    List of Tables
    Number of Products under Development by Stage of Development, H2 2017
    Number of Products under Development by Therapy Areas, H2 2017
    Number of Products under Development by Indication, H2 2017
    Number of Products under Development by Companies, H2 2017
    Products under Development by Companies, H2 2017
    Products under Development by Companies, H2 2017 (Contd..1), H2 2017
    Number of Products under Investigation by Universities/Institutes, H2 2017
    Products under Investigation by Universities/Institutes, H2 2017
    Number of Products by Stage and Mechanism of Actions, H2 2017
    Number of Products by Stage and Route of Administration, H2 2017
    Number of Products by Stage and Molecule Type, H2 2017
    Pipeline by Aeterna Zentaris Inc, H2 2017
    Pipeline by Alize Pharma SAS, H2 2017
    Pipeline by Allergan Plc, H2 2017
    Pipeline by AstraZeneca Plc, H2 2017
    Pipeline by Daiichi Sankyo Co Ltd, H2 2017
    Pipeline by Oxeia Biopharmaceuticals Inc, H2 2017
    Pipeline by Pfizer Inc, H2 2017
    Pipeline by RaQualia Pharma Inc, H2 2017
    Pipeline by Zeria Pharmaceutical Co Ltd, H2 2017
    Dormant Products, H2 2017
    Dormant Products, H2 2017 (Contd..1), H2 2017
    Dormant Products, H2 2017 (Contd..2), H2 2017
    Discontinued Products, H2 2017

    List of Figures
    Number of Products under Development by Stage of Development, H2 2017
    Number of Products under Development by Therapy Areas, H2 2017
    Number of Products under Development by Top 10 Indications, H2 2017
    Number of Products by Mechanism of Actions, H2 2017
    Number of Products by Stage and Mechanism of Actions, H2 2017
    Number of Products by Routes of Administration, H2 2017
    Number of Products by Stage and Routes of Administration, H2 2017
    Number of Products by Molecule Types, H2 2017
    Number of Products by Stage and Molecule Types, H2 2017
    Aeterna Zentaris Inc
    Alize Pharma SAS
    Allergan Plc
    AstraZeneca Plc
    Daiichi Sankyo Co Ltd
    Oxeia Biopharmaceuticals Inc
    Pfizer Inc
    RaQualia Pharma Inc
    Zeria Pharmaceutical Co Ltd

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